A Fuzzy Model of Glucose Regulation

  • Authors:
  • Em Ward;Terry Martin

  • Affiliations:
  • Biomedical and Electrical Engineering, University of Arkansas, Fayetteville Arkansas 72701;Electrical Engineering, University of Arkansas, Fayetteville 72701

  • Venue:
  • Journal of Medical Systems
  • Year:
  • 2006
  • Fuzzy Systems in Biomedicine

    Proceedings of the 2007 conference on Emerging Artificial Intelligence Applications in Computer Engineering: Real Word AI Systems with Applications in eHealth, HCI, Information Retrieval and Pervasive Technologies

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Abstract

We present a detailed glucose regulation model using fuzzy inference system (FIS) descriptions of hormonal control action and the familiar Michaelis---Menten (M---M) kinetic description for glucose transport. The fuzzy M---M model is compared and contrasted with a well-known comprehensive glucose model. The two models give similar results for glucose response, endogenous glucose production, and total uptake. The fuzzy M---M model features a renal subsystem that provides 25% of the endogenous glucose production. The work demonstrates the successful application of fuzzy logic and fuzzy inference to biological modelling. The flexibility of fuzzy inference, a linguistic description technique, permits conceptually simple statements about nonlinear processes.