Computers in Biology and Medicine
Using interesting sequences to interactively build Hidden Markov Models
Data Mining and Knowledge Discovery
ACIIDS'11 Proceedings of the Third international conference on Intelligent information and database systems - Volume Part I
Protein fold recognition with a two-layer method based on SVM-SA, WP-NN and C4.5 TLM-SNC
International Journal of Data Mining and Bioinformatics
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Protein fold recognition has been the focus of computational biologists for many years. In order to map a protein primary structure to its correct 3D fold, we introduce in this paper a machine learning paradigm that we entitled "structural hidden Markov model" (SHMM). We show how the concept of SHMM can efficiently use the protein secondary structure during the fold recognition task. Experimental results showed that the SHMMoutperforms the SVM with a 6% improvement in the average accuracy. However, because in this application the two classifiers are not correlated, therefore their combination based on the highest rank criterion boosted the SHMM average accuracy with 10%.