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CareMedia is a collaborative effort that to date has captured more than 13,000 hours of video and audio recordings of life in the shared spaces of a nursing home dementia unit, by using 23 ceiling-mounted cameras, 24 hours a day for 25 days, ensuring an un-occluded view of every point in the recorded space. Computer machine learning techniques are being applied to the resulting 25 Terabytes of data, automatically processing the record for efficient use by analytical observers (e.g., social and behavioral scientists, geriatricians, and healthcare policy makers) to monitor and understand residents' well-being, and enhance their quality of life. This truly interdisciplinary effort bridges the psychological, social and behavioral sciences, and clinical medicine with multiple engineering and computer science disciplines to establish a clinical evidence base to guide rational therapeutics, an elusive goal ardently articulated by the Institute of Medicine. This paper discusses early foundation work being conducted with the data.