HapSim: a simulation tool for generating haplotype data with pre-specified allele frequencies and LD coefficients

  • Authors:

  • Giovanni Montana

  • Affiliations:

  • Department of Mathematics, Imperial College London, UK

  • Venue:
  • Bioinformatics
  • Year:
  • 2005

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Abstract

We have developed a simulation tool HapSim for the generation of haplotype data. The simulated haplotypes are such that their allele frequencies and linkage disequilibrium coefficients match exactly those estimated in a real sample. Availability: The program is available as an R package and can be downloaded from http://cran.r-project.org/ Contact: g.montana@imperial.ac.uk