SUSPECTS: enabling fast and effective prioritization of positional candidates

Authors:
E. A. Adie;R. R. Adams;K. L. Evans;D. J. Porteous;B. S. Pickard
Affiliations:
Medical Genetics Section, School of Molecular and Clinical Medicine, University of Edinburgh EH4 2XU UK;Medical Genetics Section, School of Molecular and Clinical Medicine, University of Edinburgh EH4 2XU UK;Medical Genetics Section, School of Molecular and Clinical Medicine, University of Edinburgh EH4 2XU UK;Medical Genetics Section, School of Molecular and Clinical Medicine, University of Edinburgh EH4 2XU UK;Medical Genetics Section, School of Molecular and Clinical Medicine, University of Edinburgh EH4 2XU UK
Venue:
Bioinformatics
Year:
2006

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Abstract

Summary: SUSPECTS is a web-based server which combines annotation and sequence-based approaches to prioritize disease candidate genes in large regions of interest. It uses multiple lines of evidence to rank genes quickly and effectively while limiting the effect of annotation bias to significantly improve performance. Availability: SUSPECTS is freely available at http://www.genetics.med.ed.ac.uk/suspects/ Contact: euan.adie@ed.ac.uk Supplementary information: A quick-start guide in Macromedia Flash format is available at http://www.genetics.med.ed.ac.uk/suspects/help.shtml and Excel spreadsheets detailing the comparative performance of the software are included as Supplementary material.