An ensemble of K-local hyperplanes for predicting protein--protein interactions

  • Authors:
  • Loris Nanni;Alessandra Lumini

  • Affiliations:
  • DEIS, IEIIT, CNR, Università di Bologna Viale Risorgimento 2, 40136 Bologna, Italy;DEIS, IEIIT, CNR, Università di Bologna Viale Risorgimento 2, 40136 Bologna, Italy

  • Venue:
  • Bioinformatics
  • Year:
  • 2006

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Abstract

Prediction of protein--protein interaction is a difficult and important problem in biology. In this paper, we propose a new method based on an ensemble of K-local hyperplane distance nearest neighbor (HKNN) classifiers, where each HKNN is trained using a different physicochemical property of the amino acids. Moreover, we propose a new encoding technique that combines the amino acid indices together with the 2-Grams amino acid composition. A fusion of HKNN classifiers combined with the 'Sum rule' enables us to obtain an improvement over other state-of-the-art methods. The approach is demonstrated by building a learning system based on experimentally validated protein--protein interactions in human gastric bacterium Helicobacter pylori and in Human dataset. Contact: lnanni@deis.unibo.it