Assigning roles to protein mentions: The case of transcription factors
Journal of Biomedical Informatics
| Hi-index | 3.84 |
Summary: We present a manually annotated catalogue of site-specific transcription factors (TFs) in the fruit fly Drosophila melanogaster. These were identified from a list of candidate proteins with transcription-related Gene Ontology (Go) annotation as well as structural DNA-binding domain assignments. For all 1052 candidate proteins, a defined set of rules was applied to classify information from the literature and computational data sources with respect to both DNA-binding and transcriptional regulatory properties. We propose a set of 753 TFs in the fruit fly, of which 23 are confident novel predictions of this function for previously uncharacterized proteins. Availability: http://www.flytf.org/ Contact: boris@mrc-lmb.cam.ac.uk Supplementary information: Supplementary data are available at http://www.flytf.org/