Computational Explorations in Cognitive Neuroscience: Understanding the Mind by Simulating the Brain
Computational Explorations in Cognitive Neuroscience: Understanding the Mind by Simulating the Brain
Opponent interactions between serotonin and dopamine
Neural Networks - Computational models of neuromodulation
Learning to Predict by the Methods of Temporal Differences
Machine Learning
Biological Cybernetics
Rapid decision threshold modulation by reward rate in a neural network
Neural Networks - 2006 Special issue: Neurobiology of decision making
Rapid decision threshold modulation by reward rate in a neural network
Neural Networks - 2006 Special issue: Neurobiology of decision making
Adaptive Behavior - Animals, Animats, Software Agents, Robots, Adaptive Systems
Stop and go: The neural basis of selective movement prevention
Journal of Cognitive Neuroscience
Initiation and termination of integration in a decision process
Neural Networks
A biophysical network model displaying the role of basal ganglia pathways in action selection
ICANN'12 Proceedings of the 22nd international conference on Artificial Neural Networks and Machine Learning - Volume Part I
The subthalamic nucleus influences visuospatial attention in humans
Journal of Cognitive Neuroscience
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The basal ganglia (BG) coordinate decision making processes by facilitating adaptive frontal motor commands while suppressing others. In previous work, neural network simulations accounted for response selection deficits associated with BG dopamine depletion in Parkinson's disease. Novel predictions from this model have been subsequently confirmed in Parkinson patients and in healthy participants under pharmacological challenge. Nevertheless, one clear limitation of that model is in its omission of the subthalamic nucleus (STN), a key BG structure that participates in both motor and cognitive processes. The present model incorporates the STN and shows that by modulating when a response is executed, the STN reduces premature responding and therefore has substantial effects on which response is ultimately selected, particularly when there are multiple competing responses. Increased cortical response conflict leads to dynamic adjustments in response thresholds via cortico-subthalamic-pallidal pathways. The model accurately captures the dynamics of activity in various BG areas during response selection. Simulated dopamine depletion results in emergent oscillatory activity in BG structures, which has been linked with Parkinson's tremor. Finally, the model accounts for the beneficial effects of STN lesions on these oscillations, but suggests that this benefit may come at the expense of impaired decision making.