An introduction to genetic algorithms
An introduction to genetic algorithms
Pattern Classification (2nd Edition)
Pattern Classification (2nd Edition)
Modern Applied Statistics with S
Modern Applied Statistics with S
Using genetic programming & neural networks for learner evaluation
AIKED'08 Proceedings of the 7th WSEAS International Conference on Artificial intelligence, knowledge engineering and data bases
The Development of a Self-assessment System for the Learners Answers with the Use of GPNN
WSKS '08 Proceedings of the 1st world summit on The Knowledge Society: Emerging Technologies and Information Systems for the Knowledge Society
IEEE Transactions on Information Technology in Biomedicine - Special section on computational intelligence in medical systems
Investigation into effectiveness of rough sets in prediction of enzyme and protein structure classes
IJCNN'09 Proceedings of the 2009 international joint conference on Neural Networks
A survey on the application of genetic programming to classification
IEEE Transactions on Systems, Man, and Cybernetics, Part C: Applications and Reviews
The power of quantitative grammatical evolution neural networks to detect gene-gene interactions
Proceedings of the 13th annual conference on Genetic and evolutionary computation
Two layered Genetic Programming for mixed-attribute data classification
Applied Soft Computing
HAIS'10 Proceedings of the 5th international conference on Hybrid Artificial Intelligence Systems - Volume Part I
International Journal of Bio-Inspired Computation
Review article: Computational intelligence techniques in bioinformatics
Computational Biology and Chemistry
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The identification of genes that influence the risk of common, complex disease primarily through interactions with other genes and environmental factors remains a statistical and computational challenge in genetic epidemiology. This challenge is partly due to the limitations of parametric statistical methods for detecting genetic effects that are dependent solely or partially on interactions. We have previously introduced a genetic programming neural network (GPNN) as a method for optimizing the architecture of a neural network to improve the identification of genetic and gene-environment combinations associated with disease risk. Previous empirical studies suggest GPNN has excellent power for identifying gene-gene and gene-environment interactions. The goal of this study was to compare the power of GPNN to stepwise logistic regression (SLR) and classification and regression trees (CART) for identifying gene-gene and gene-environment interactions. SLR and CART are standard methods of analysis for genetic association studies. Using simulated data, we show that GPNN has higher power to identify gene-gene and gene-environment interactions than SLR and CART. These results indicate that GPNN may be a useful pattern recognition approach for detecting gene-gene and gene-environment interactions in studies of human disease.