Formulation of ELF magnetic fields' effects on malondialdehyde level and myeloperoxidase activity in kidney using genetic programming

  • Authors:

  • Gülay Tohumoglu;Ayşe G. Canseven;Abdulkadir Çevik;Nesrin Seyhan

  • Affiliations:

  • Electrical and Electronics Engineering, University of Gaziantep, 27310 Gaziantep, Turkey;Department of Biophysics, Faculty of Medicine, Gazi University, 06510 Ankara, Turkey;Civil Engineering, University of Gaziantep, 27310 Gaziantep, Turkey;Department of Biophysics, Faculty of Medicine, Gazi University, 06510 Ankara, Turkey

  • Venue:
  • Computer Methods and Programs in Biomedicine
  • Year:
  • 2007

Quantified Score

Hi-index 0.01

Visualization

Abstract

In vivo exposure effects of electromagnetic fields (EMFs) on various tissues of experiment animals have been investigated. In this sense, modeling and formulation of these biological effects have been of significant importance. In this study extremely low frequency (ELF) EMFs effects on malondialdehyde (MDA) level and myeloperoxidase (MPO) activity in kidney of guinea pigs exposed to 50Hz magnetic fields of 1mT, 2mT and 3mT have been presented. It has been planned to determine whether genetic programming (GP) is appropriate to analyze and formulate these biological effects. Consequently, it has been observed that GP can be effectively used to model MDA level and MPO activity. The performances of prediction of the proposed GP formulation versus actual experimental values are found to be quite satisfactory in terms of standard deviation and correlation coefficient. It is concluded that the GP application serves to form a database for the researchers in this field, without exposing tissues to EMF and without using too many guinea pigs.