A multi-scale computational method applied to the quantitative evaluation of the left ventricular function

  • Authors:

  • Fuyou Liang;Hisashi Taniguchi;Hao Liu

  • Affiliations:

  • Graduate School of Science and Technology, Chiba University, Chiba, Japan;Graduate School of Science and Technology, Chiba University, Chiba, Japan;Graduate School of Science and Technology, Chiba University, Chiba, Japan and Department of Electronics and Mechanical Engineering, Chiba University, Chiba, Japan

  • Venue:
  • Computers in Biology and Medicine
  • Year:
  • 2007

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Abstract

A multi-scale computational method, which combines a lumped parameter model of the cardiovascular system (CVS) with a three-dimensional (3D) left ventricle (LV) hemodynamic solver, is developed for quantitatively evaluating the LV function. The parameter model allows reasonable predictions of the cardiac variables in a closed-loop manner under both normal and various pathological conditions. On the basis of the parameter-model-predicted results, 3D hemodynamic computations further provide quantitative insights into the detailed intraventricular flow patterns. Based on a series of computations, it is demonstrated that the pathological change in the shape and size of the LV has a significant effect on the LV pumping performance.