Theta-modulated input reduces intrinsic gamma oscillations in a hippocampal model

Authors:
Ashlie B. Hocking;William B. Levy
Affiliations:
Department of Neurosurgery, University of Virginia, Charlottesville, VA, USA and Department of Computer Science, University of Virginia, Charlottesville, VA, USA;Department of Neurosurgery, University of Virginia, Charlottesville, VA, USA
Venue:
Neurocomputing
Year:
2007

Citing 3
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2005 Special issue: Interpreting hippocampal function as recoding and forecasting

Neural Networks - Special issue: Computational theories of the functions of the hippocampus
Gamma oscillations in a minimal CA3 model

Neurocomputing
Simple model of spiking neurons

IEEE Transactions on Neural Networks

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Abstract

Introducing theta-modulated input into a minimal model of the CA3 region of the hippocampus has significant effects on gamma oscillations. In the absence of theta-modulated input, the gamma oscillations are robust across a range of parameters. Introducing theta-modulated input weakens the gamma oscillations to a power more consistent with power spectra acquired from laboratory animals. With these changes, simulations of the hippocampal model are able to reproduce hippocampal power spectra measured in awake mice.