Feature Selection on High Throughput SELDI-TOF Mass-Spectrometry Data for Identifying Biomarker Candidates in Ovarian and Prostate Cancer

  • Authors:

  • Claudia Plant;Melanie Osl;Bernhard Tilg;Christian Baumgartner

  • Affiliations:

  • University for Health Sciences, Biomedical Informatics and Technology (UMIT), Hall in Tirol, Austria;University for Health Sciences, Biomedical Informatics and Technology (UMIT), Hall in Tirol, Austria;University for Health Sciences, Biomedical Informatics and Technology (UMIT), Hall in Tirol, Austria;University for Health Sciences, Biomedical Informatics and Technology (UMIT), Hall in Tirol, Austria

  • Venue:
  • ICDMW '06 Proceedings of the Sixth IEEE International Conference on Data Mining - Workshops
  • Year:
  • 2006

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Abstract

High-throughput mass-spectrometry screening has the potential of superior results in detecting early stage cancer than traditional biomarkers. Proteomic data poses novel challenges for data mining, especially concerning the curse of dimensionality. In this paper, we present a 3-step feature selection framework combining the advantages of efficient filter and effective wrapper techniques. We demonstrate the performance of our framework on two SELDITOF- MS data sets for identifying biomarker candidates in ovarian and prostate cancer.