Analysis of the magnetoencephalogram background activity in Alzheimer's disease patients with auto-mutual information

  • Authors:

  • Carlos Gómez;Roberto Hornero;Daniel Abásolo;Alberto Fernández;Javier Escudero

  • Affiliations:

  • Biomedical Engineering Group, E. T. S. Ingenieros de Telecomunicación, University of Valladolid, Camino del Cementerio s/n, 47011-Valladolid, Spain;Biomedical Engineering Group, E. T. S. Ingenieros de Telecomunicación, University of Valladolid, Camino del Cementerio s/n, 47011-Valladolid, Spain;Biomedical Engineering Group, E. T. S. Ingenieros de Telecomunicación, University of Valladolid, Camino del Cementerio s/n, 47011-Valladolid, Spain;Centro de Magnetoencefalografía Dr. Pérez-Modrego, Complutense University of Madrid, Spain;Biomedical Engineering Group, E. T. S. Ingenieros de Telecomunicación, University of Valladolid, Camino del Cementerio s/n, 47011-Valladolid, Spain

  • Venue:
  • Computer Methods and Programs in Biomedicine
  • Year:
  • 2007

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Abstract

The aim of the present study was to analyse the magnetoencephalogram (MEG) background activity in patients with Alzheimer's disease (AD), one of the most frequent disorders among elderly population. For this pilot study, we recorded the MEGs with a 148-channel whole-head magnetometer in 20 patients with probable AD and 21 age-matched control subjects. Artefact-free epochs of 3392 samples were analysed with auto-mutual information (AMI). Average AMI decline rates were lower for the AD patients' recordings than for control subjects' ones. Statistically significant differences were found using a Student's t-test (p