Modelling and control of HIV dynamics

Authors:
Alberto Landi;Alberto Mazzoldi;Chiara Andreoni;Matteo Bianchi;Andrea Cavallini;Marco Laurino;Leonardo Ricotti;Rodolfo Iuliano;Barbara Matteoli;Luca Ceccherini-Nelli
Affiliations:
Department of Electrical Systems and Automation, University of Pisa, Pisa, Italy;Interdepartmental Research Center E. Piaggio, University of Pisa, Pisa, Italy;University of Pisa, Italy;University of Pisa, Italy;University of Pisa, Italy;University of Pisa, Italy;University of Pisa, Italy;Department of Experimental Pathology, Virology Section, University of Pisa, Pisa, Italy;Department of Experimental Pathology, Virology Section, University of Pisa, Pisa, Italy;Department of Experimental Pathology, Virology Section, University of Pisa, Pisa, Italy
Venue:
Computer Methods and Programs in Biomedicine
Year:
2008

Citing 1
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Abstract

Various models of HIV infection and evolution have been considered in the literature. This paper considers a variant of the Wodarz and Nowak mathematical model, adding ''aggressiveness'' as a new state variable in order to quantify the strength of the virus and its response to drugs. Although the model proposed is relatively simple, simulation results suggest that it may be useful in predicting the impact of the effectiveness of therapy on HIV dynamics.