Two Methods for Improving Performance of a HMM and their Application for Gene Finding
Proceedings of the 5th International Conference on Intelligent Systems for Molecular Biology
An evolutionary algorithm for gene structure prediction
IEA/AIE'11 Proceedings of the 24th international conference on Industrial engineering and other applications of applied intelligent systems conference on Modern approaches in applied intelligence - Volume Part II
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Gene prediction is still an important step to annotate genomes. In this paper, we proposed a novel method for recognizing gene in genomes. The method combines three famous gene-finding programs. After calculating the accuracy parameters, the equitable weight for each parameter is calculated using genetic algorithm. Then the integrative evaluation is performed. The integrative evaluation is employed to instruct the training of an artificial neural network. The simulation results show that the proposed method integrates advantages of three programs and the accuracy has an obvious improvement, which indicate that the proposed method has a powerful capability for gene prediction.