Technical Comment: 'Genome order index' should not be used for defining compositional constraints in nucleotide sequences

  • Authors:

  • Eran Elhaik;Dan Graur;Krešimir Josić

  • Affiliations:

  • Department of Biology & Biochemistry, University of Houston, Houston, TX 77204-5001, USA;Department of Biology & Biochemistry, University of Houston, Houston, TX 77204-5001, USA;Department of Mathematics, University of Houston, Houston, TX 77204-3008, USA

  • Venue:
  • Computational Biology and Chemistry
  • Year:
  • 2008

Quantified Score

Hi-index 0.00

Visualization

Abstract

A ''genome order index,'' defined as S=a^2+c^2+t^2+g^2, where a, c, t, and g are the nucleotide frequencies of A, C, T, and G, respectively, was used to suggest that there exist genome-specific constraints on nucleotide composition. We show that the ''evidence'' for constraint, S