Brief communication: A nucleotide composition constraint of genome sequences

  • Authors:

  • Chun-Ting Zhang;Ren Zhang

  • Affiliations:

  • Department of Physics, Tianjin University, Tianjin 300072, China;Department of Epidemiology and Biostatistics, Tianjin Cancer Institute and Hospital, Tianjin 300060, China

  • Venue:
  • Computational Biology and Chemistry
  • Year:
  • 2004

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Abstract

Let a, c, g and t denote the occurrence frequencies of A, C, G and T, respectively, in a genome. We calculated the statistical quantity S=a^2+c^2+g^2+t^2 for each of 809 genomes (11 archaea, 42 bacteria, 3 eukaryota, 90 phages, 36 viroids and 627 viruses) and 236 plasmids. We found that S