A matrix-based multilevel approach to identify functional protein modules

  • Authors:
  • Suely Oliveira;Sang-Cheol Seok

  • Affiliations:
  • Department of Computer Science, The University of Iowa, Iowa City, 52242 IA, USA.;Department of Computer Science, The University of Iowa, Iowa City, 52242 IA, USA

  • Venue:
  • International Journal of Bioinformatics Research and Applications
  • Year:
  • 2008

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Abstract

Identifying functional modules is believed to reveal most cellular processes. There have been many computational approaches to investigate the underlying biological structures (Bader and Hogue, 2003; Dhillon et al., 2005; Krogan et al., 2006; Ramadan et al., 2005; Xiong et al., 2005; Zhang et al., 2004). A spectral clustering method plays a critical role identifying functional modules in a yeast protein-protein network (Ramadan et al., 2005). We present an unweighted-graph version of a multilevel spectral algorithm which more accurately identifies protein complexes with less computational time.