Automatic verification of finite-state concurrent systems using temporal logic specifications
ACM Transactions on Programming Languages and Systems (TOPLAS)
The PEPA workbench: a tool to support a process algebra-based approach to performance modelling
Proceedings of the 7th international conference on Computer performance evaluation : modelling techniques and tools: modelling techniques and tools
A compositional approach to performance modelling
A compositional approach to performance modelling
Model-checking continuous-time Markov chains
ACM Transactions on Computational Logic (TOCL)
Information Processing Letters
Model-Checking Algorithms for Continuous-Time Markov Chains
IEEE Transactions on Software Engineering
Probabilistic symbolic model checking with PRISM: a hybrid approach
International Journal on Software Tools for Technology Transfer (STTT) - Special section on tools and algorithms for the construction and analysis of systems
Probabilistic model checking in practice: case studies with PRISM
ACM SIGMETRICS Performance Evaluation Review
Model Checking Markov Reward Models with Impulse Rewards
DSN '05 Proceedings of the 2005 International Conference on Dependable Systems and Networks
QEST '05 Proceedings of the Second International Conference on the Quantitative Evaluation of Systems
Numerical vs. statistical probabilistic model checking
International Journal on Software Tools for Technology Transfer (STTT)
Cell Cycle Control in Eukaryotes: A BioSpi model
Electronic Notes in Theoretical Computer Science (ENTCS)
GRIP: Generic Representatives in PRISM
QEST '07 Proceedings of the Fourth International Conference on Quantitative Evaluation of Systems
Model checking the probabilistic pi-calculus
QEST '07 Proceedings of the Fourth International Conference on Quantitative Evaluation of Systems
Probabilistic model checking of complex biological pathways
Theoretical Computer Science
SFM'07 Proceedings of the 7th international conference on Formal methods for performance evaluation
Efficient, correct simulation of biological processes in the stochastic pi-calculus
CMSB'07 Proceedings of the 2007 international conference on Computational methods in systems biology
Towards probabilistic model checking on p systems using PRISM
WMC'06 Proceedings of the 7th international conference on Membrane Computing
Analysis of signalling pathways using continuous time markov chains
Transactions on Computational Systems Biology VI
Symmetry reduction for probabilistic model checking
CAV'06 Proceedings of the 18th international conference on Computer Aided Verification
Ymer: a statistical model checker
CAV'05 Proceedings of the 17th international conference on Computer Aided Verification
Transactions on Computational Systems Biology VII
PRISM: a tool for automatic verification of probabilistic systems
TACAS'06 Proceedings of the 12th international conference on Tools and Algorithms for the Construction and Analysis of Systems
CMSB '08 Proceedings of the 6th International Conference on Computational Methods in Systems Biology
CSL Model Checking of Biochemical Networks with Interval Decision Diagrams
CMSB '09 Proceedings of the 7th International Conference on Computational Methods in Systems Biology
Approximate Model Checking of PCTL Involving Unbounded Path Properties
ICFEM '09 Proceedings of the 11th International Conference on Formal Engineering Methods: Formal Methods and Software Engineering
On the connections between PCTL and dynamic programming
Proceedings of the 13th ACM international conference on Hybrid systems: computation and control
A comparative study of stochastic analysis techniques
Proceedings of the 8th International Conference on Computational Methods in Systems Biology
Biomodel engineering – from structure to behavior
Transactions on Computational Systems Biology XII
ACM Transactions on Software Engineering and Methodology (TOSEM)
Probabilistic abstract interpretation
ESOP'12 Proceedings of the 21st European conference on Programming Languages and Systems
Multiple verification in complex biological systems: the bone remodelling case study
Transactions on Computational Systems Biology XIV
Probabilistic model checking of the PDGF signaling pathway
Transactions on Computational Systems Biology XIV
A Software Interface Between the Narrative Language and Bio-PEPA
Electronic Notes in Theoretical Computer Science (ENTCS)
IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)
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Probabilistic model checking is a formal verification framework for systems which exhibit stochastic behaviour. It has been successfully applied to a wide range of domains, including security and communication protocols, distributed algorithms and power management. In this paper we demonstrate its applicability to the analysis of biological pathways and show how it can yield a better understanding of the dynamics of these systems. Through a case study of the MAP (Mitogen-Activated Protein) Kinase cascade, we explain how biological pathways can be modelled in the probabilistic model checker PRISM and how this enables the analysis of a rich selection of quantitative properties.