Assessing clinical trial eligibility with logic expression queries

Authors:
D. W. Lonsdale;C. Tustison;C. G. Parker;D. W. Embley
Affiliations:
Brigham Young University, Provo, UT 84602, USA;Brigham Young University, Provo, UT 84602, USA;Brigham Young University, Provo, UT 84602, USA;Brigham Young University, Provo, UT 84602, USA
Venue:
Data & Knowledge Engineering
Year:
2008

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Abstract

This paper introduces a system that processes clinical trials using a combination of natural language processing and database techniques. We process web-based clinical trial recruitment pages to extract semantic information reflecting eligibility criteria for potential participants. From this information we then formulate a query that can match criteria against medical data in patient records. The resulting system reflects a tight coupling of web-based information extraction, natural language processing, medical informatic approaches to clinical knowledge representation, and large-scale database technologies. We present an evaluation of the system and future directions for further system development.