A vector space model for automatic indexing
Communications of the ACM
Neural Networks for Pattern Recognition
Neural Networks for Pattern Recognition
Genetic Algorithms in Search, Optimization and Machine Learning
Genetic Algorithms in Search, Optimization and Machine Learning
Modern Information Retrieval
Practical Genetic Algorithms with CD-ROM
Practical Genetic Algorithms with CD-ROM
Encyclopedia Of Data Warehousing And Mining
Encyclopedia Of Data Warehousing And Mining
Induction of comprehensible models for gene expression datasets by subgroup discovery methodology
Journal of Biomedical Informatics - Special issue: Biomedical machine learning
Journal of Parallel and Distributed Computing
SequenceLDhot: detecting recombination hotspots
Bioinformatics
Cancer gene search with data-mining and genetic algorithms
Computers in Biology and Medicine
Recursive structure element decomposition using migration fitness scaling genetic algorithm
ICSI'11 Proceedings of the Second international conference on Advances in swarm intelligence - Volume Part I
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This paper describes a novel algorithm to analyze genetic linkage data using pattern recognition techniques and genetic algorithms (GA). The method allows a search for regions of the chromosome that may contain genetic variations that jointly predispose individuals for a particular disease. The method uses correlation analysis, filtering theory and genetic algorithms to achieve this goal. Because current genome scans use from hundreds to hundreds of thousands of markers, two versions of the method have been implemented. The first is an exhaustive analysis version that can be used to visualize, explore, and analyze small genetic data sets for two marker correlations; the second is a GA version, which uses a parallel implementation allowing searches of higher-order correlations in large data sets. Results on simulated data sets indicate that the method can be informative in the identification of major disease loci and gene-gene interactions in genome-wide linkage data and that further exploration of these techniques is justified. The results presented for both variants of the method show that it can help genetic epidemiologists to identify promising combinations of genetic factors that might predispose to complex disorders. In particular, the correlation analysis of IBD expression patterns might hint to possible gene-gene interactions and the filtering might be a fruitful approach to distinguish true correlation signals from noise.