Anesthesia with propofol slows atrial fibrillation dominant frequencies

Authors:
R. Cervigón;J. Moreno;F. Castells;J. Mateo;C. Sánchez;J. Pérez-Villacastín;J. Millet
Affiliations:
Escuela Universitaria Politécnica, Campus Universitario, Innovation in Bioengineering Research Group (GIBI), DIEEAC, UCLM, Camino del Pozuelo sn, 16071 Cuenca, Spain;Unidad de Arritmias, Hospital Clínico San Carlos, Plaza de Cristo Rey sn, 28040 Madrid, Spain;Universidad Politécnica de Valencia, Bioengineering Electronic Telemedicine (BET), DIE, Camino de la Vera sn, 46022 Valencia, Spain;Escuela Universitaria Politécnica, Campus Universitario, Innovation in Bioengineering Research Group (GIBI), DIEEAC, UCLM, Camino del Pozuelo sn, 16071 Cuenca, Spain;Escuela Universitaria Politécnica, Campus Universitario, Innovation in Bioengineering Research Group (GIBI), DIEEAC, UCLM, Camino del Pozuelo sn, 16071 Cuenca, Spain;Unidad de Arritmias, Hospital Clínico San Carlos, Plaza de Cristo Rey sn, 28040 Madrid, Spain;Universidad Politécnica de Valencia, Bioengineering Electronic Telemedicine (BET), DIE, Camino de la Vera sn, 46022 Valencia, Spain
Venue:
Computers in Biology and Medicine
Year:
2008

Citing 1
Cited 1

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Abstract

The mechanisms responsible for the maintenance of atrial fibrillation (AF) are not completely understood yet. It has been demonstrated that AF can be modulated by several cardiac diseases, the autonomic nervous system and even drugs with purportedly no antiarrhythmic properties. We evaluated the effects of a widely used anaesthetic agent (propofol) in the fibrillation patterns. Spectral analysis was performed over atrial electrograms at baseline and immediately after a propofol bolus. Only after performing principal component analysis (PCA), we were able to significantly detect that propofol slows AF.