Continuous drug infusion for diabetes therapy: a closed-loop control system design

Authors:
Jiming Chen;Kejie Cao;Youxian Sun;Yang Xiao;Xu Su
Affiliations:
State Key Laboratory of Industrial Control Technology, Institute of Industrial Process Control, Zhejiang University, Hangzhou, China;State Key Laboratory of Industrial Control Technology, Institute of Industrial Process Control, Zhejiang University, Hangzhou, China;State Key Laboratory of Industrial Control Technology, Institute of Industrial Process Control, Zhejiang University, Hangzhou, China;Department of Computer Science, The University of Alabama, Tuscaloosa, AL;Department of Computer Science, University of Texas at San Antonio, San Antonio, TX
Venue:
EURASIP Journal on Wireless Communications and Networking - Wireless Telemedicine and Applications
Year:
2008

Citing 4
Cited 5

Fuzzy Control and Fuzzy Systems

Fuzzy Control and Fuzzy Systems
Feedback Control of Dynamic Systems

Feedback Control of Dynamic Systems
A survey of insulin-dependent diabetes-part I: therapies and devices

International Journal of Telemedicine and Applications - Regular issue
Computer-aided continuous drug infusion: setup and test of a mobile closed-loop system for the continuous automated infusion of insulin

IEEE Transactions on Information Technology in Biomedicine

Temperature-aware routing for telemedicine applications in embedded biomedical sensor networks

EURASIP Journal on Wireless Communications and Networking - Wireless Telemedicine and Applications
A survey of insulin-dependent diabetes-part I: therapies and devices

International Journal of Telemedicine and Applications - Regular issue
Ubiquitous computing for remote cardiac patient monitoring: a survey

International Journal of Telemedicine and Applications - Regular issue
A survey of insulin-dependent diabetes-part II: control methods

International Journal of Telemedicine and Applications - Regular issue
Neural network and physiological parameters based control of artificial pancreas for improved patient safety

ICCSA'12 Proceedings of the 12th international conference on Computational Science and Its Applications - Volume Part III

Quantified Score

Hi-index	0.00

Visualization

Abstract

While a typical way for diabetes therapy is discrete insulin infusion based on long-time interval measurement, in this paper, we design a closed-loop control system for continuous drug infusion to improve the traditional discrete methods and make diabetes therapy automatic in practice. By exploring the accumulative function of drug to insulin, a continuous injection model is proposed. Based on this model, proportional-integral-derivative (PID) and fuzzy logic controllers are designed to tackle a control problem of the resulting highly nonlinear plant. Even with serious disturbance of glucose, such as nutrition absorption at meal time, the proposed scheme can perform well in simulation experiments.