Information storage and retrieval
Information storage and retrieval
Foundations of statistical natural language processing
Foundations of statistical natural language processing
Modern Information Retrieval
Probabilistic question answering on the Web: Research Articles
Journal of the American Society for Information Science and Technology
A knowledge-driven approach to cluster validity assessment
Bioinformatics
A Vector Space Search Engine forWeb Services
ECOWS '05 Proceedings of the Third European Conference on Web Services
Measuring semantic similarity between Gene Ontology terms
Data & Knowledge Engineering
A go-driven semantic similarity measure for quantifying the biological relatedness of gene products
Intelligent Decision Technologies - Special issue on advances in medical intelligent decision support systems
Evaluating data mining algorithms using molecular dynamics trajectories
International Journal of Data Mining and Bioinformatics
Identifying significant associations of orthologous simple sequence repeats with gene ontologies
International Journal of Data Mining and Bioinformatics
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We propose an approach for quantifying the biological relatedness between gene products, based on their properties, and measure their similarities using exclusively statistical NLP techniques and Gene Ontology (GO) annotations. We also present a novel similarity figure of merit, based on the vector space model, which assesses gene expression analysis results and scores gene product clusters' biological coherency, making sole use of their annotation terms and textual descriptions. We define query profiles which rapidly detect a gene product cluster's dominant biological properties. Experimental results validate our approach, and illustrate a strong correlation between our coherency score and gene expression patterns.