Extracting Grammars from RNA Sequences

  • Authors:
  • Gabriela Andrejková;Helena Lengeňová;Michal Mati

  • Affiliations:
  • Institute of Computer Science, Faculty of Science, P. J. Šafárik University, Košice, Slovakia;Institute of Computer Science, Faculty of Science, P. J. Šafárik University, Košice, Slovakia;Institute of Computer Science, Faculty of Science, P. J. Šafárik University, Košice, Slovakia

  • Venue:
  • ICANNGA '07 Proceedings of the 8th international conference on Adaptive and Natural Computing Algorithms, Part I
  • Year:
  • 2007

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Abstract

In the paper, we describe an application of stochastic context-free grammars (SCFG) to modelling of the formal RNA string language. The simplification of the stochastic context-free grammar and it's conversion to Chomsky normal form was used. We present the modification of Cocke-Kasami-Younger algorithm that is used for probabilistic estimations of stochastic grammars for RNA sequences. Some better algorithms were constructed to decrease the computational complexity but still on the level of O(n3) where nis the length of the RNA strings. The results of using the algorithms to the training sample consisted of tRNA chains of Acinetobacter sp. bactery are described.