Statecharts: A visual formalism for complex systems
Science of Computer Programming
Design patterns: elements of reusable object-oriented software
Design patterns: elements of reusable object-oriented software
Dynamic structures in modeling and simulation: a reflective approach
ACM Transactions on Modeling and Computer Simulation (TOMACS)
Information Processing Letters
Theory of Modeling and Simulation
Theory of Modeling and Simulation
An Overview and Synthesis on Timed Process Algebras
CAV '91 Proceedings of the 3rd International Workshop on Computer Aided Verification
A component-based simulation layer for JAMES
Proceedings of the eighteenth workshop on Parallel and distributed simulation
BioAmbients: an abstraction for biological compartments
Theoretical Computer Science - Special issue: Computational systems biology
Developing An Hierarchical Simulator for Beta-binders
Proceedings of the 20th Workshop on Principles of Advanced and Distributed Simulation
Introducing variable ports and multi-couplings for cell biological modeling in DEVS
Proceedings of the 38th conference on Winter simulation
A non-fragmenting partitioning algorithm for hierarchical models
Proceedings of the 38th conference on Winter simulation
Composing simulations from XML-specified model components
Proceedings of the 38th conference on Winter simulation
ANSS '07 Proceedings of the 40th Annual Simulation Symposium
A Spatial Extension to the π Calculus
Electronic Notes in Theoretical Computer Science (ENTCS)
Composing simulation models using interface definitions based on web service descriptions
Proceedings of the 39th conference on Winter simulation: 40 years! The best is yet to come
Combining micro and macro-modeling in DEVS for computational biology
Proceedings of the 39th conference on Winter simulation: 40 years! The best is yet to come
Parallel and Distributed Spatial Simulation of Chemical Reactions
Proceedings of the 22nd Workshop on Principles of Advanced and Distributed Simulation
An Algorithm Selection Approach for Simulation Systems
Proceedings of the 22nd Workshop on Principles of Advanced and Distributed Simulation
The event queue problem and PDevs
SpringSim '07 Proceedings of the 2007 spring simulation multiconference - Volume 2
An automated translation from a narrative language for biological modelling into process algebra
CMSB'07 Proceedings of the 2007 international conference on Computational methods in systems biology
Beta binders for biological interactions
CMSB'04 Proceedings of the 20 international conference on Computational Methods in Systems Biology
Component-Based Modelling of RNA Structure Folding
CMSB '08 Proceedings of the 6th International Conference on Computational Methods in Systems Biology
Large-Scale Design Space Exploration of SSA
CMSB '08 Proceedings of the 6th International Conference on Computational Methods in Systems Biology
JAMES II: extending, using, and experiments
Proceedings of the 5th International ICST Conference on Simulation Tools and Techniques
Tutorial on building M&S software based on reuse
Proceedings of the Winter Simulation Conference
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Diverse modelling formalisms are applied in Computational Biology. Some describe the biological system in a continuous manner, others focus on discrete-event systems, or on a combination of continuous and discrete descriptions. Similarly, there are many simulators that support different formalisms and execution types (e.g. sequential, parallel-distributed) of one and the same model. The latter is often done to increase efficiency, sometimes at the cost of accuracy and level of detail. James IIhas been developed to support different modelling formalisms and different simulators and their combinations. It is based on a plug-in concept which enables developers to integrate spatial and non-spatial modelling formalisms (e.g. stochastic茂戮驴calculus, Beta binders, Devs, space-茂戮驴), simulation algorithms (e.g. variants of Gillespie's algorithms (including Tau Leaping and Next Subvolume Method),space-茂戮驴simulator, parallel Beta binderssimulator) and supporting technologies (e.g. partitioning algorithms, data collection mechanisms, data structures, random number generators) into an existing framework. This eases method development and result evaluation in applied modelling and simulation as well as in modelling and simulation research.