Computational Modeling of Genetic and Biochemical Networks (Computational Molecular Biology)
Computational Modeling of Genetic and Biochemical Networks (Computational Molecular Biology)
Integrating clinical and genomic information through the prognochip mediator
ISBMDA'06 Proceedings of the 7th international conference on Biological and Medical Data Analysis
Supporting clinico-genomic knowledge discovery: a multi-strategy data mining process
SETN'06 Proceedings of the 4th Helenic conference on Advances in Artificial Intelligence
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The complex regulatory mechanisms of genes and their transcription are the major gene regulatory steps in the cell. Gene Regulatory Networks (GRNs) and DNA Microarrays (MAs) present two of the most prominent and heavily researched concepts in contemporary molecular biology and bioinformatics. The challenge in contemporary biomedical informatics research lies in systems biology - the linking of various pillars of heterogeneous data so they can be used in synergy for life science research. Faced with this challenge we devised and present an integrated methodology that `amalgamates' knowledge and data from both GRNs and MA gene expression sources. The methodology, is able to identify phenotype-specific GRN functional paths, and aims to uncover potential gene-regulatory `fingerprints' and molecular mechanisms that govern the genomic profiles of diseases. Initial implementation and experimental results on a real-world breast-cancer study demonstrate the suitability and reliability of the approach.