AGN Simulation and Validation Model

Authors:
Fabrício M. Lopes;Roberto M. Cesar, Jr;Luciano F. Costa
Affiliations:
Instituto de Matemática e Estatística, Universidade de São Paulo, Brazil and Universidade Tecnológica Federal do Paraná, Brazil;Instituto de Matemática e Estatística, Universidade de São Paulo, Brazil;Instituto de Física de São Carlos, Universidade de São Paulo, Brazil
Venue:
BSB '08 Proceedings of the 3rd Brazilian symposium on Bioinformatics: Advances in Bioinformatics and Computational Biology
Year:
2008

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Abstract

An important question in computational biology is how genes are regulated and interact through gene networks. Some methods for the identification of gene networks from temporal data were proposed. An important open problem regards how to validate such resulting networks. This work presents an approach to validate such algorithms, considering three main aspects: (1) AGN model generation and simulation; (2) gene network identification; (3) validation of identified network.