Floating search methods in feature selection
Pattern Recognition Letters
Adaptive floating search methods in feature selection
Pattern Recognition Letters - Special issue on pattern recognition in practice VI
Coefficient of determination in nonlinear signal processing
Signal Processing - Special section on signal processing technologies for short burst wireless communications
Fast Branch & Bound Algorithms for Optimal Feature Selection
IEEE Transactions on Pattern Analysis and Machine Intelligence
IEEE Transactions on Pattern Analysis and Machine Intelligence
Growing genetic regulatory networks from seed genes
Bioinformatics
Inferring Connectivity of Genetic Regulatory Networks Using Information-Theoretic Criteria
IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)
Inference of gene regulatory networks based on a universal minimum description length
EURASIP Journal on Bioinformatics and Systems Biology
AGN Simulation and Validation Model
BSB '08 Proceedings of the 3rd Brazilian symposium on Bioinformatics: Advances in Bioinformatics and Computational Biology
Conditioning-Based Modeling of Contextual Genomic Regulation
IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB)
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An important problem in the bioinformatics field is the inference of gene regulatory networks (GRN) from temporal expression profiles. In general, the main limitations faced by GRN inference methods is the small number of samples with huge dimensionalities and the noisy nature of the expression measurements. In face of these limitations, alternatives are needed to get better accuracy on the GRNs inference problem. In this context, this work addresses this problemby presenting an alternative feature selection method that applies prior knowledge on its search strategy, called SFFS-MR. The proposed search strategy is based on SFFS algorithm, with the inclusion of multiple roots at the beginning of the search, which are defined by the best and worst single results of the SFS algorithm. In this way, the search space traversed is guided by these roots in order to find the predictor genes for a given target gene, specially to better identify genes presenting intrinsically multivariate prediction, without worsening the asymptotical computational cost of the SFFS. Experimental results show that the SFFS-MR provides a better inference accuracy than SFS and SFFS, maintaining a similar robustness of the SFS and SFFS methods. In addition, the SFFS-MR was able to achieve 60% of accuracy on network recovery after only 20 observations from a state space of size 220, thus presenting very good results.