Summarizing Multiple Gene Trees Using Cluster Networks

  • Authors:
  • Daniel H. Huson;Regula Rupp

  • Affiliations:
  • Center for Bioinformatics ZBIT, Tübingen University, Tübingen, Germany 72076;Center for Bioinformatics ZBIT, Tübingen University, Tübingen, Germany 72076

  • Venue:
  • WABI '08 Proceedings of the 8th international workshop on Algorithms in Bioinformatics
  • Year:
  • 2008

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Abstract

The result of a multiple gene tree analysis is usually a number of different tree topologies that are each supported by a significant proportion of the genes. We introduce the concept of a cluster network that can be used to combine such trees into a single rooted network, which can be drawn either as a cladogram or phylogram. In contrast to split networks, which can grow exponentially in the size of the input, cluster networks grow only quadratically. A cluster network is easily computed using a modification of the tree-popping algorithm, which we call network-popping. The approach has been implemented as part of the Dendroscope tree-drawing program and its application is illustrated using data and results from three recent studies on large numbers of gene trees.