Brief paper: Fast algorithms for nonparametric population modeling of large data sets

  • Authors:
  • Gianluigi Pillonetto;Giuseppe De Nicolao;Marco Chierici;Claudio Cobelli

  • Affiliations:
  • Dipartimento di Ingegneria dell'Informazione, University of Padova, Italy;Dipartimento di Informatica e Sistemistica, University of Pavia, Italy;Predictive Models for Biomedicine and Environment Unit, Fondazione Bruno Kessler, Trento, Italy;Dipartimento di Ingegneria dell'Informazione, University of Padova, Italy

  • Venue:
  • Automatica (Journal of IFAC)
  • Year:
  • 2009

Quantified Score

Hi-index 22.15

Visualization

Abstract

Population models are widely applied in biomedical data analysis since they characterize both the average and individual responses of a population of subjects. In the absence of a reliable mechanistic model, one can resort to the Bayesian nonparametric approach that models the individual curves as Gaussian processes. This paper develops an efficient computational scheme for estimating the average and individual curves from large data sets collected in standardized experiments, i.e. with a fixed sampling schedule. It is shown that the overall scheme exhibits a ''client-server'' architecture. The server is in charge of handling and processing the collective data base of past experiments. The clients ask the server for the information needed to reconstruct the individual curve in a single new experiment. This architecture allows the clients to take advantage of the overall data set without violating possible privacy and confidentiality constraints and with negligible computational effort.