IEEE Transactions on Pattern Analysis and Machine Intelligence
The Random Subspace Method for Constructing Decision Forests
IEEE Transactions on Pattern Analysis and Machine Intelligence
Genetic Algorithms in Search, Optimization and Machine Learning
Genetic Algorithms in Search, Optimization and Machine Learning
Machine Learning
Neural Network Methodology for 1H NMR Spectroscopy Classification
ICIIS '99 Proceedings of the 1999 International Conference on Information Intelligence and Systems
Pattern Classification (2nd Edition)
Pattern Classification (2nd Edition)
MCS'07 Proceedings of the 7th international conference on Multiple classifier systems
Selective Ensemble under Regularization Framework
MCS '09 Proceedings of the 8th International Workshop on Multiple Classifier Systems
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A new approach for the automatic detection of drug-induced organ toxicities based on Nuclear Magnetic Resonance Spectroscopy data from biofluids is presented in this paper. Spectral data from biofluids contain information on the concentration of various substances, but the combination of only a small subset of these cues is putatively useful for classification of new samples. We propose to divide the spectra into several short regions and train classifiers on them, using only a limited amount of information for class discrimination. These local experts are combined in an ensemble classification system and the subset of experts for the final classification is optimized automatically. Thus, only local experts for relevant spectral regions are used for the final ensemble classification. The proposed approach has been evaluated on a real data-set from industrial pharmacology, showing an improvement in classification accuracy and indicating relevant spectral regions for classification.