Vesicle-synapsin interactions modeled with Cell-DEVS

Authors:
Rhys Goldstein;Gabriel Wainer;James J. Cheetham;Roderick S. Bain
Affiliations:
Carleton University, Ottawa, ON, Canada;Carleton University, Ottawa, ON, Canada;Carleton University, Ottawa, ON, Canada;Carleton University, Ottawa, ON, Canada
Venue:
Proceedings of the 40th Conference on Winter Simulation
Year:
2008

Citing 4
Cited 1

A new kind of science

A new kind of science
Theory of Modeling and Simulation

Theory of Modeling and Simulation
N-dimensional Cell-DEVS Models

Discrete Event Dynamic Systems
CD++: a toolkit to develop DEVS models

Software—Practice & Experience

DEVS-based design of spatial simulations of biological systems

Winter Simulation Conference

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Abstract

Interactions between synaptic vesicles and synapsin in a presynaptic nerve terminal were modeled using the Cell-DEVS formalism. Vesicles and synapsins move randomly within the presynaptic compartment. Synapsins can bind to more than one vesicle simultaneously, causing clusters to form. Phosphorylation of synapsin reduces its affinity for vesicles, and causes the clusters to break apart. Upon dephosphosphorylation, new clusters form. Taking advantage of Cell-DEVS, as opposed to traditional techniques for implementing cellular automata, the model prevents collisions between arbitrarily large clusters using transition rules restricted to a 5-cell neighborhood. Simulation results indicate that, in a qualitative sense, the behavior of vesicles and synapsin in neurons was captured.