DEVS formalism and methodology: unity of conception/diversity of application
WSC '93 Proceedings of the 25th conference on Winter simulation
Theory of Modeling and Simulation
Theory of Modeling and Simulation
Vesicle-synapsin interactions modeled with Cell-DEVS
Proceedings of the 40th Conference on Winter Simulation
Multi-resolution spatial simulation for molecular crowding
Proceedings of the 40th Conference on Winter Simulation
Discrete-Event Modeling and Simulation: A Practitioner's Approach
Discrete-Event Modeling and Simulation: A Practitioner's Approach
Spatial modeling in cell biology at multiple levels
Proceedings of the Winter Simulation Conference
| Hi-index | 0.00 |
The application of the DEVS formalism to spatial simulations of biological systems is motivated by a need to keep software manageable, even when faced with complex models that may combine algorithms for potential fields, fluid dynamics, the interaction of proteins, or the reaction and diffusion of chemicals. We demonstrate DEVS-based design by applying the formalism to a "tethered particle system" (TPS), a model we designed to capture the motion of deformable biological structures. The paper focuses on the design of DEVS models using hierarchies and layers, and describes a recently-developed simulator that supports our approach. The DEVS-based TPS model, which has been used to simulate certain interactions in nerve cells, demonstrates the formalism's potential as a means of addressing the complexity of spatial biological models.