A Task-Specific Ontology for the Application and Critiquing of Time-Oriented Clinical Guidelines
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Journal of Biomedical Informatics
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Artificial Intelligence in Medicine
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Clinical guidelines adaptation: managing authoring and versioning issues
AIME'05 Proceedings of the 10th conference on Artificial Intelligence in Medicine
Artificial Intelligence in Medicine
A modular approach for representing and executing clinical guidelines
Artificial Intelligence in Medicine
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Artificial Intelligence in Medicine
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Artificial Intelligence in Medicine
Authoring and verification of clinical guidelines: A model driven approach
Journal of Biomedical Informatics
Updating a protocol-based decision-support system's knowledge base: a breast cancer case study
KR4HC'10 Proceedings of the ECAI 2010 conference on Knowledge representation for health-care
Exploitation of translational bioinformatics for decision-making on cancer treatments
ITBAM'11 Proceedings of the Second international conference on Information technology in bio- and medical informatics
Efficient management of multi-version clinical guidelines
Journal of Biomedical Informatics
Methodological Review: Computer-interpretable clinical guidelines: A methodological review
Journal of Biomedical Informatics
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Objective: Clinical practice guidelines (CPGs) are means to provide evidence-based medical knowledge. In order to make up-to-date ''best'' scientific evidence available these documents need to be updated on an ongoing basis. An effective method to accomplish this aim is offered by the so-called ''living guidelines'': Living guidelines are documents presenting up-to-date and state-of-the-art knowledge to practitioners. To have guidelines implemented by computer-support they have to be formalized in a computer-interpretable form in a first step. Due to the complexity of such formats the formalization process is burdensome and time-consuming. Automating parts of the modeling process and, consequently, modeling updates of these guideline documents are demanded. Methods and material: The LASSIE methodology supports this task by formalizing guidelines in several steps from the textual form to the guideline representation language Asbru using a document-centric approach. LASSIE uses information extraction techniques to semi-automatically accomplish these steps. We apply LASSIE to support the implementation of living guidelines. Results: Based on a living guideline published by the Scottish Intercollegiate Guidelines Network (SIGN) we show that adaptations of previously formalized guidelines can be accomplished easily and fast. Thereby, the different versions of guideline documents are compared and updates are identified. Due to the traceable formalization method of linking text parts and their corresponding formal models, we are able to inherit unchanged models from previously formalized versions. Thus, we only need to formalize updated text parts using the semi-automatic formalization method LASSIE. Conclusion: We propose a simple, time-saving, but effective method called LASSIE to formalize new guideline versions of previously formalized CPGs. Furthermore, models that have been added or modified by knowledge engineers in previous versions can also be transferred easily. This will result in a faster implementation of new guideline versions also known as living guidelines to provide up-to-date knowledge necessary for accomplishing the daily work of health care professionals.