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Dependence is a common relationship between objects. Many works have paid their attentions on dependence, but many of them mainly focus on constructing or exploiting dependence graphs on some specific domain. In this paper, we give a generic definition of dependence and make equivalence to the situation of graphs, and propose an algorithm called DepRank, which quantifies the dependence degree of a node pair based on probabilities of all dependence paths. Empirical study shows that DepRank method has reasonable results and maintains a well balance between accuracy and efficiency.