The use of relational database commands in retrieval of pedigree information
Journal of Medical Systems
A Graph Query Language and Its Query Processing
ICDE '99 Proceedings of the 15th International Conference on Data Engineering
PViN: a scalable and flexible system for visualizing pedigree databases
Proceedings of the 2005 ACM symposium on Applied computing
A Framework for Querying Pedigree Data
SSDBM '06 Proceedings of the 18th International Conference on Scientific and Statistical Database Management
Efficient Evaluation of Inbreeding Queries on Pedigree Data
SSDBM '07 Proceedings of the 19th International Conference on Scientific and Statistical Database Management
Efficient query evaluation for DAG-shaped hierarchies
Proceedings of the First ACM International Conference on Bioinformatics and Computational Biology
Using compact encodings for path-based computations on pedigree graphs
Proceedings of the 2nd ACM Conference on Bioinformatics, Computational Biology and Biomedicine
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We consider pedigree data structured in the form of a directed acyclic graph, and use an encoding scheme, called NodeCodes, for expediting the evaluation of queries on pedigree graph structures. Inbreeding is the quantitative measure of the genetic relationship between two individuals. The inbreeding coefficient is related to the probability that both copies of any given gene are received from the same ancestor. In this paper we discuss the evaluation of the inbreeding coefficient of a given individual using NodeCodes and propose a new encoding scheme, Family NodeCodes, which is further optimized for pedigree graphs. We implemented and tested these approaches on both synthetic and real pedigree data in terms of performance and scalability. Experimental results show that the use of NodeCodes provides a good alternative for queries involving the inbreeding coefficient, with significant improvements over the traditional iterative evaluation methods (up to 10.1 times faster), and Family NodeCodes further improves this to 77.1 times faster while using 91% less space than regular NodeCodes.