Using compact encodings for path-based computations on pedigree graphs

  • Authors:
  • Lei Yang;En Cheng;Z. Meral Özsoyoǧlu

  • Affiliations:
  • Case Western Reserve University;Case Western Reserve University;Case Western Reserve University

  • Venue:
  • Proceedings of the 2nd ACM Conference on Bioinformatics, Computational Biology and Biomedicine
  • Year:
  • 2011

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Abstract

With increasingly growing knowledge of genetics and rapid accumulation of genealogy information, pedigree data is becoming very important. Efficiently identifying all pedigree paths for an individual plays an important role in computing genealogical measurements such as inbreeding and kinship coefficients of individuals. In this paper, we propose a new compact path encoding scheme, and present an efficient scheme for identifying paths on large pedigrees to enable path-based computations on pedigree graphs. We also use inbreeding coefficient computation as an example to demonstrate the space and time efficiency of our method. Compact Path Encoding scheme for path manipulations is applicable to general directed acyclic graphs in general. We perform experiments for comparing the efficiency of our method with the previous methods for evaluating inbreeding coefficients on pedigree graphs with real and synthetic data sets. Experimental results demonstrate that the resulting scheme is more scalable and efficient than previous methods both in terms of time and space requirements.