Genetic circuit building blocks for cellular computation, communications, and signal processing
Natural Computing: an international journal
Digital Design: Principles and Practices (4th Edition)
Digital Design: Principles and Practices (4th Edition)
A Computer Scientist's Guide to Cell Biology
A Computer Scientist's Guide to Cell Biology
Automatic design of optimal logic circuits based on ternary quantum-dot cellular automata
WSEAS Transactions on Circuits and Systems
Computer
Algebraic model for the behaviour of a D-flip-flops-based memory component
MAMECTIS'10 Proceedings of the 12th WSEAS international conference on Mathematical methods, computational techniques and intelligent systems
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We present the model of a first digital synchronous sequential circuit, i.e. 1-bit synchronous counter, which is about to be realized within the living cell. Mathematical model was constructed upon gene expression based logic with ordinary differential equations (ODEs), particularly Hill equations. The behaviour of the counter was simulated in Matlab/Simulink environment. With the promising simulation results presented in the paper physical realization of the circuit described within the living cell can be initiated. Introduction of synchronization with a special signal, i.e. clock signal, brings many benefits to the field. Realization of such circuit would therefore present an important step toward the construction of complex biological information processing capable systems.