Discovery of functional miRNA-mRNA regulatory modules with computational methods

Authors:
Bing Liu;Jiuyong Li;Anna Tsykin
Affiliations:
School of Computer and Information Science, University of South Australia, Mawson Lakes, SA 5095, Australia;School of Computer and Information Science, University of South Australia, Mawson Lakes, SA 5095, Australia;Hanson Institute and Division of Human Immunology, Institute of Medical and Veterinary Science, Australia
Venue:
Journal of Biomedical Informatics
Year:
2009

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Abstract

The identification of miRNAs and their target mRNAs and the construction of their regulatory networks may give new insights into biological procedures. This study proposes a computational method to discover the functional miRNA-mRNA regulatory modules (FMRMs), that is, groups of miRNAs and their target mRNAs that are believed to participate cooperatively in post-transcriptional gene regulation under specific conditions. The proposed method identifies negatively regulated patterns of miRNAs and mRNAs which associate with cancer and normal conditions, respectively, in a prostate cancer data set. GO and the literature also suggest that they may relate with prostate cancer. It can potentially identify the biologically relevant chains of 'miRNA-target gene - condition'.