EST-PAGE---managing and analyzing EST data
Bioinformatics
Identification of plant microRNA homologs
Bioinformatics
Computational Biology and Chemistry
Discovery of functional miRNA-mRNA regulatory modules with computational methods
Journal of Biomedical Informatics
Research Article: Ranking of microRNA target prediction scores by Pareto front analysis
Computational Biology and Chemistry
Computers in Biology and Medicine
Proceedings of the CUBE International Information Technology Conference
In silico analysis of putative miRNAs and their target genes in sorghum Sorghum bicolor
International Journal of Bioinformatics Research and Applications
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MicroRNAs (miRNAs) are one class of newly identified riboregulators of gene expression in many eukaryotic organisms. They play important roles in multiple biological and metabolic processes, including developmental timing, signal transduction, cell maintenance and differentiation, diseases and cancers. miRNAs regulate gene expression at the posttranscriptional level by directly cleaving targeted mRNAs or repressing translation. Although the founding members of miRNAs were discovered by genetic screening approaches, experimental approaches were limited by their low efficiency, time consuming, and high cost. As an alternative, computational approaches were developed. Computational approaches for identifying miRNAs are based on the following major characteristics of miRNAs: hairpin-shaped secondary structures, high conservation for some miRNAs, and high minimal folding free energy index (MFEI). Computational approaches also play an important role in identifying miRNA targets. A majority of known miRNAs and their targets were identified by computational approaches. Several web-based or non-web-based computer software programs are publicly available for predicting miRNAs and their targets.