CVODE, a stiff/nonstiff ODE solver in C
Computers in Physics
Evolving petri nets to represent metabolic pathways
GECCO '05 Proceedings of the 7th annual conference on Genetic and evolutionary computation
Simulation of biochemical networks using COPASI: a complex pathway simulator
Proceedings of the 38th conference on Winter simulation
Bioinformatics
EvoBIO '09 Proceedings of the 7th European Conference on Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics
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In Systems Biology, there is a growing need for simulation and optimization tools for the prediction of the phenotypical behavior of microorganisms. In this paper, an open-source software platform is proposed to provide support for research in Metabolic Engineering, by implementing tools that enable the simulation and optimization of dynamic metabolic models using ordinary differential equations. Its main functionalities are related with (i) phenotype simulation of both wild type and mutant strains under given environmental conditions and (ii) strain optimization tackling tasks such as gene knockout selection or the definition of the optimal level of enzyme expression, given appropriate objective functions. The central carbon metabolism of E. coli was used as a case study, to illustrate the main features of the software.