Incremental Kernel Machines for Protein Remote Homology Detection

  • Authors:
  • Lionel Morgado;Carlos Pereira

  • Affiliations:
  • CISUC - Center for Informatics and Systems of the University of Coimbra Polo II, Universidade de Coimbra, Coimbra, Portugal 3030-290;CISUC - Center for Informatics and Systems of the University of Coimbra Polo II, Universidade de Coimbra, Coimbra, Portugal 3030-290 and ISEC - Instituto Superior de Engenharia de Coimbra Quinta d ...

  • Venue:
  • HAIS '09 Proceedings of the 4th International Conference on Hybrid Artificial Intelligence Systems
  • Year:
  • 2009

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Abstract

Protein membership prediction is a fundamental task to retrieve information for unknown or unidentified sequences. When support vector machines (SVMs) are associated with the right kernels, this machine learning technique can build state-of-the-art classifiers. However, traditional implementations work in a batch fashion, limiting the application to very large and high dimensional data sets, typical in biology. Incremental SVMs introduce an alternative to batch algorithms, and a good candidate to solve these problems. In this work several experiments are conducted to evaluate the performance of the incremental SVM on remote homology detection using a benchmark data set. The main advantages are shown, opening the possibility to further improve the algorithm in order to achieve even better classifiers.