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Mobile devices can be used to provide assistance to people with cognitive impairments wherever they go and increase their independence. Due to the limited capacities of the target users and the constraints related to mobile devices, special care must be used when developing software. In this paper, guidelines are proposed to help in designing mobile assistive technologies for people suffering from cognitive disabilities. Examples of these guidelines application are given in the context of MOBUS: a system providing cognitive assistance and tele-monitoring of daily activities.