An unsupervised clustering approach for leukaemia classification based on DNA micro-arrays data

  • Authors:
  • Simone Garatti;Sergio Bittanti;Diego Liberati;Andrea Maffezzoli

  • Affiliations:
  • Department of Electronics and Information, Milan Polytechinics, Piazza Leonardo da Vinci 32, 20133 Milan, Italy. E-mail: {bittanti,sgaratti}@elet.polimi.it;Department of Electronics and Information, Milan Polytechinics, Piazza Leonardo da Vinci 32, 20133 Milan, Italy. E-mail: {bittanti,sgaratti}@elet.polimi.it;Institute of Electronics, Information and Telecommunication Engineering, National Research Council, Milan, Italy. E-mail: liberati@elet.polimi.it;Department of Bioengineering, Milan Polytechnics, Piazza Leonardo da Vinci 32, 20133 Milan, Italy

  • Venue:
  • Intelligent Data Analysis
  • Year:
  • 2007

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Abstract

DNA micro-arrays provide thousands of genomic expressions on the same subject. A main issue is then to find the subset of genes whose degeneration is responsible of a certain type of cancer. In this paper, starting from a paradigmatic classification problem of two kinds of Leukaemia, we discuss the use of data-mining techniques in such a context. Particular attention is devoted not only to the classification method but also to all the data analysis steps including data pre-processing and information retrieval.