Principal Warps: Thin-Plate Splines and the Decomposition of Deformations
IEEE Transactions on Pattern Analysis and Machine Intelligence
Multiresolution elastic matching
Computer Vision, Graphics, and Image Processing
Landmark-Based Image Analysis: Using Geometric and Intensity Models
Landmark-Based Image Analysis: Using Geometric and Intensity Models
A Multiresolution Algorithm for Signal and Image Registration
ICIP '97 Proceedings of the 1997 International Conference on Image Processing (ICIP '97) 3-Volume Set-Volume 3 - Volume 3
Journal of Signal Processing Systems
ISBI'10 Proceedings of the 2010 IEEE international conference on Biomedical imaging: from nano to Macro
Computer-aided prognosis: predicting patient and disease outcome via multi-modal image analysis
ISBI'10 Proceedings of the 2010 IEEE international conference on Biomedical imaging: from nano to Macro
Automatic classification of lymphoma images with transform-based global features
IEEE Transactions on Information Technology in Biomedicine
Pattern recognition in histopathological images: an ICPR 2010 contest
ICPR'10 Proceedings of the 20th International conference on Recognizing patterns in signals, speech, images, and videos
Histology image analysis for carcinoma detection and grading
Computer Methods and Programs in Biomedicine
Computer-aided techniques for chromogenic immunohistochemistry: Status and directions
Computers in Biology and Medicine
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Follicular lymphoma (FL) is the second most common type of non-Hodgkin's lymphoma. Manual histological grading of FL is subject to remarkable inter- and intra-reader variations. A promising approach to grading is the development of a computer-assisted system that improves consistency and precision. Correlating information from adjacent slides with different stain types requires establishing spatial correspondences between the digitized section pair through a precise non-rigid image registration. However, the dissimilar appearances of the different stain types challenges existing registration methods. This study proposes a method for the automatic non-rigid registration of histological section images with different stain types. This method is based on matching high level features that are representative of small anatomical structures. This choice of feature provides a rich matching environment, but also results in a high mismatch probability. Matching confidence is increased by establishing local groups of coherent features through geometric reasoning. The proposed method is validated on a set of FL images representing different disease stages. Statistical analysis demonstrates that given a proper feature set the accuracy of automatic registration is comparable to manual registration.