An evolutionary method for combining different feature selection criteria in microarray data classification

Authors:
Nicoletta Dessì;Barbara Pes
Affiliations:
Dipartimento di Matematica e Informatica, Università degli Studi di Cagliari, Cagliari, Italy;Dipartimento di Matematica e Informatica, Università degli Studi di Cagliari, Cagliari, Italy
Venue:
Journal of Artificial Evolution and Applications - Special issue on artificial evolution methods in the biological and biomedical sciences
Year:
2009

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Abstract

The classification of cancers from gene expression profiles is a challenging research area in bioinformatics since the high dimensionality of microarray data results in irrelevant and redundant information that affects the performance of classification. This paper proposes using an evolutionary algorithm to select relevant gene subsets in order to further use them for the classification task. This is achieved by combining valuable results from different feature ranking methods into feature pools whose dimensionality is reduced by a wrapper approach involving a genetic algorithm and SVM classifier. Specifically, the GA explores the space defined by each feature pool looking for solutions that balance the size of the feature subsets and their classification accuracy. Experiments demonstrate that the proposed method provide good results in comparison to different state of art methods for the classification of microarray data.