Characterization of clustered microcalcifications in digitized mammograms using neural networks and support vector machines

  • Authors:
  • A. Papadopoulos;D. I. Fotiadis;A. Likas

  • Affiliations:
  • Department of Medical Physics, Medical School, University of Ioannina, GR 45110 Ioannina, Greece and Department of Computer Science, University of Ioannina, Unit of Medical Technology and Intellig ...;Department of Computer Science, University of Ioannina, Unit of Medical Technology and Intelligent Information Systems, and Biomedical Research Institute-FORTH, GR 45110 Ioannina, Greece;Department of Computer Science, University of Ioannina, Unit of Medical Technology and Intelligent Information Systems, and Biomedical Research Institute-FORTH, GR 45110 Ioannina, Greece

  • Venue:
  • Artificial Intelligence in Medicine
  • Year:
  • 2005

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Abstract

Objective: : Detection and characterization of microcalcification clusters in mammograms is vital in daily clinical practice. The scope of this work is to present a novel computer-based automated method for the characterization of microcalcification clusters in digitized mammograms. Methods and material: : The proposed method has been implemented in three stages: (a) the cluster detection stage to identify clusters of microcalcifications, (b) the feature extraction stage to compute the important features of each cluster and (c) the classification stage, which provides with the final characterization. In the classification stage, a rule-based system, an artificial neural network (ANN) and a support vector machine (SVM) have been implemented and evaluated using receiver operating characteristic (ROC) analysis. The proposed method was evaluated using the Nijmegen and Mammographic Image Analysis Society (MIAS) mammographic databases. The original feature set was enhanced by the addition of four rule-based features. Results and conclusions: : In the case of Nijmegen dataset, the performance of the SVM was A"z=0.79 and 0.77 for the original and enhanced feature set, respectively, while for the MIAS dataset the corresponding characterization scores were A"z=0.81 and 0.80. Utilizing neural network classification methodology, the corresponding performance for the Nijmegen dataset was A"z=0.70 and 0.76 while for the MIAS dataset it was A"z=0.73 and 0.78. Although the obtained high classification performance can be successfully applied to microcalcification clusters characterization, further studies must be carried out for the clinical evaluation of the system using larger datasets. The use of additional features originating either from the image itself (such as cluster location and orientation) or from the patient data may further improve the diagnostic value of the system.