Downgrading BIRADS 3 to BIRADS 2 category using a computer-aided microcalcification analysis and risk assessment system for early breast cancer

  • Authors:

  • Georgia Giannakopoulou;George M. Spyrou;Argyro Antaraki;Ioannis Andreadis;Dimitra Koulocheri;Flora Zagouri;Afroditi Nonni;George M. Filippakis;Konstantina S. Nikita;Panos A. Ligomenides;George C. Zografos

  • Affiliations:

  • Breast Unit, 1st Department of Propaedeutic Surgery, Hippokratio Hospital, School of Medicine, University of Athens, 114, Vas. Sofias Avenue, 11527 Athens, Greece and Breast Unit, 1st Department o ...;Informatics Laboratory, Academy of Athens, 4, Soranou Ephessiou St., 115 27, Greece and Biomedical Informatics Unit, Biomedical Research Foundation, Academy of Athens, 4, Soranou Ephessiou St., 11 ...;Informatics Laboratory, Academy of Athens, 4, Soranou Ephessiou St., 115 27, Greece;Informatics Laboratory, Academy of Athens, 4, Soranou Ephessiou St., 115 27, Greece and Department of Electrical and Computer Engineering, National Technical University of Athens, 9 Iroon Polytexn ...;Breast Unit, 1st Department of Propaedeutic Surgery, Hippokratio Hospital, School of Medicine, University of Athens, 114, Vas. Sofias Avenue, 11527 Athens, Greece and Department of Radiology, Hipp ...;Breast Unit, 1st Department of Propaedeutic Surgery, Hippokratio Hospital, School of Medicine, University of Athens, 114, Vas. Sofias Avenue, 11527 Athens, Greece;Department of Pathology, School of Medicine, University of Athens, 75 Mikras Asias St., 115 27Athens, Greece;Breast Unit, 1st Department of Propaedeutic Surgery, Hippokratio Hospital, School of Medicine, University of Athens, 114, Vas. Sofias Avenue, 11527 Athens, Greece;Department of Electrical and Computer Engineering, National Technical University of Athens, 9 Iroon Polytexneiou St., 157 80 Athens, Greece;Informatics Laboratory, Academy of Athens, 4, Soranou Ephessiou St., 115 27, Greece;Breast Unit, 1st Department of Propaedeutic Surgery, Hippokratio Hospital, School of Medicine, University of Athens, 114, Vas. Sofias Avenue, 11527 Athens, Greece

  • Venue:
  • Computers in Biology and Medicine
  • Year:
  • 2010

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Abstract

This paper explores the potential of a computer-aided diagnosis system to discriminate the real benign microcalcifications among a specific subset of 109 patients with BIRADS 3 mammograms who had undergone biopsy, thus making it possible to downgrade them to BIRADS 2 category. The system detected and quantified critical features of microcalcifications and classified them on a risk percentage scale for malignancy. The system successfully detected all cancers. Nevertheless, it suggested biopsy for 11/15 atypical lesions. Finally, the system characterized as definitely benign (BIRADS 2) 29/88 benign lesions, previously assigned to BIRADS 3, and thus achieved a reduction of 33% in unnecessary biopsies.